Why beagle experiments don’t work

Goldenthal claims that his experiments will save human lives. However he is not working for the good of humanity, but for his own profits. There is no need to experiment on beagle dogs. Due to the physiological differences between beagles and humans, drugs have different effects on the two species. When Viagra was tested on beagles, they showed “beagle pain syndrome,” experiencing  side effects such as arching of the back and neck stiffness that do not apply to humans. When the female contraceptive DMPA was tested on beagle dogs, the results were also extremely misleading. There are many ways to ensure the safety of new drugs without testing on animals. Methods such as computer modelling and in-vitro tests involving cultured cells are cheaper, quicker and more reliable. The physiological and biochemical differences between humans and animals mean that the results of animal tests cannot be reliably applied to humans.

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  1. There are many ,many cases of drugs that have been tested on animals backfiring and killing humans .when they are relesed onto the market.Goldenthals beagle testing venture is nothing but profiting from poisoning animals there is nothing scientific about it at all.To see some real scientists who know what they are on about and advocate valid non animal research visit
    http://www.curedisease.net

  2. I was shocked to read the following rubbish in the U.K. Guardian of all newspapers. It is disgusting and I hope people will write to the newspaper to let them know it is totally false and experiments on dogs are archaic and have no place in modern research.
    You can also find this disgsting article on the web:

    UK news U.K.Guardian
    Ethical reasons why beagles have to dieAnimal research HLS defends its production line.

    Paul Kelso The Guardian, Saturday 24 February 2001 01.55 GMT Article historyBuffalo, a large, soppy-eyed beagle, is taking his exercise at Huntingdon Life Sciences. For 20 minutes he and 23 other beagles are released from their 6ft x 6ft pens and allowed to trot up and down the 60ft passage that separates the cages. Buffalo grubs at a plastic bone, and nuzzles one of his colleagues before being scooped up into the arms of his handler. “Hello my lovely, my little baby,” she says, staring down with eyes almost as soppy as his. She has given all the dogs names she says, but Buffalo is her favourite.
    Buffalo is 12 weeks into his life at Huntingdon, which has the capacity to house more than 1,000 beagles. He is used to the routine; he takes his breakfast, dosed with the substance he is here to test, at around 9am before being returned to the pen. Once an hour to a chorus of excited yelps, a technician walks the passage looking for signs of adverse reactions to the substance.

    Commercial confidentiality prevents HLS from revealing the nature of the substance Buffalo and co are being exposed to but it could be an agri-chemical, a drug or a food additive. Once a week Buffalo is taken out and weighed, his urine and faeces collected for analysis, and once a month a blood sample is taken. In 40 weeks when the trial is concluded Buffalo will have reached the end of his useful life and will be killed with barbiturates, along with all the other dogs in the trial.

    This is when the real work begins. Postmortems will be conducted. Samples of all major organs will be taken, slides prepared and treated before being passed to HLS’s laboratories where the effects of the substance on the dogs are assessed. Meanwhile the next round of testing will have begun. Buffalo’s pen will have been hosed down and another beagle will have taken his place.

    This unsentimental production line is the way of animal-based research, and very few companies do more of it than HLS, Europe’s largest contract research organisation.

    Speaking three days before he was attacked by hooded men as he returned home on Thursday night, Brian Cass, the managing director and chief executive, bristled at the criticism levelled against HLS by Shac, Stop Huntingdon Life Cruelty, whose campaign has forced HLS to defend its methods and aims to an unprecedented degree.

    “We live in a society that demands absolute safety in everything, in the environment, driving your car, the food you eat and the medicines you take. Government has responded to that by seeking the best body of scientific advice available and laying down a series of safety tests which must be carried out for all of these chemicals,” he said.

    “All the work that is done here is governed by probably the toughest piece of legislation governing research anywhere in the world. The first question we have to ask before beginning a project is, ‘can the objectives of this study be met by using non-animal studies?’ If there isn’t then you begin to discuss animal studies. The legislation requires that you use the minimum number of animals and cause the absolute minimum amount of distress.”

    Cass insists that other methods of research, including computer modelling and in vitro simulations of human organs, are not sufficiently developed. “We would all like to believe that one day it would be possible to ensure these levels of safety without using animals but the human body…is a highly complex mechanism that no one really understands.

    “Everybody that works here has made an ethical decision about their role,” says Cass. “Working here you are in a position where you are challenged in a way you are not if you are making springs or beans. Normal everyday people are doing this work and the last thing they want to see is an animal in distress. The biggest safeguard we have is the people doing the work, because you cannot carry out this research without caring about animals and if you care about them you want high welfare and low stress.”

    Demands

    Around half of the research at HLS involves animals and is designed to meet the Animal Scientific Procedures Act (1986) which demands that a wide range of drugs, food additives, industrial chemicals and domestic products is tested before being released on to the market. Animals are dosed orally, intravenously or by inhalation to examine the effects of agri-chemicals on fish and other farmed animals in simulated environments. As a result around 70,000 dogs, monkeys, rats, mice, geese, pigs, sheep, fish, honeybees and earthworms are killed at HLS every year.

    As we tour the laboratories and animal facilities, the latest in a long line of journalists invited in to HLS in a determined counter-offensive, Cass’s faith in his employees’ ethical rigour seems justified. Battered by the campaign which characterised them as torturers and in one case “a murdering paedophile”, they are at pains to explain the welfare procedures and to justify their roles. The only subject they tip-toe round is death. No one uses the word kill. Animals are “put to sleep”, “put down”, even “terminated”, but none is killed.

    In the primate unit Brian (not his real name) is responsible for HLS’s colony of crab-eating macaques. In a low windowless room they are housed between three and six to a cage, each equipped with swings, tyres, forage food trays and pipes similar to those you would see in a zoo. As we enter the monkeys chirrup and swing for their visitors. A technician in overalls, yellow gauntlets, white apron, face mask and protective goggles steps into the cage and one sits on his shoulder and begins to groom him. These animals are dosed daily by oral gavage, a tube pushed down into the stomach to ensure the entire dose is ingested.

    “These are the animals of last resort,” says Brian as we chatter back at the macaques and stroke their bald, tattooed chests through the bars. “They are captive bred before transport, so the life they have here is the same as that they have always known. Yes these animals are going to die, but while they’re alive we try and give them as good a life as possible. We never like to put them down but when we do we try and do it with respect,” he says gently.

    “We have people working here who have chosen to work with animals as their career. To characterise them as torturers and such like is an insult. Since the campaign started I have thought about chucking it all in but I’m not going to.”

    Under current legislation and according to the dominant body of scientific opinion, animal testing is a necessary stage in the development of everything from cancer treatments to coffee sweeteners. Shac and others argue that the use of animals is immoral, ethically unsound and bad science. Greg Avery, Shac’s founder, equates the campaign to the ANC’s struggle against apartheid and compares pro-animal testing arguments to those Hitler used to justify eugenics.

    In between the two sit the vast majority, beneficiaries of medicines and sweet coffee but uncomfortable with the idea of puppies and pussycats dying in the process. Shac and HLS have one thing in common; they know where they stand. So too does Buffalo’s handler, who sees no contradiction in loving and caring for an animal bred to die.

    Useful links:
    Huntingdon Life Sciences
    UK Bioindustry Association
    Stop Huntingdon Animal Cruelty

    Long road to new drugs

    • In 1999, the last year for which figures are available, 1,408 licences for testing were granted and 2,656,753 animal experiments took place in UK labs. More than 50% of these were conducted on rodents.

    • It takes, on average, eight years and £330m to bring a new medicine from the laboratory to the pharmacist.

    • In the early stages, substances are screened for known toxins.

    • The second phase, which can last up to two years, involves animals. Legislation requires that drugs are tested on two mammals, one of them a large non-rodent.

    • Following the animal stage, which can last up to two years, clinical trials on humans begin. There are three stages of clinical trials, usually beginning with the most seriously ill sufferers of a particular ailment. Only when these tests are satisfactory is the drug put on to the market.

    • Opponents of animal testing advocate using lab-based reconstructions (in vitro) and computer modelling (in silico).

  3. please keep posting on this blog. love and strength. LL. Im at expresstruth @ wordpress xo

  4. what a load of utter bollox >
    .The footage shot by michelle rooke in 1997 is the reason that ive been a member of shac for many years,and completely controdicts any of the above !!obviously they are putting on a show.if in fact you have been ther at all or are just as they are utter liars i have seen footage of monkeys been dragged from barron cages in HLS kicking screaming and biting,extremley stressed so much it reduced me to tears.Sometimes these tubes put down the throats of animals which includes beagles aswell ends up going down the throat the wrong way into the airway and into the lungs these animals then die an extremley painfull death or have to be destroyed asap.My partner who used to work for a company called rackline !! Before i met him installed some shelving systems at HLS before he knew too much about the company.Built sheves to house jars full of dead rats.3 million in total !! He said it was the most god auwful place he has ever been to in his life,and that the smell of the place was unbearable.He told the company that he worked for RACKLINE he was never prepared to go back there that he could not get the smell off him or his clothes for days and that he will never forget that stench .Now he knows exactly what goes on in that hell hole it sickens him and me that he ever set foot in that place let alone did work for them.Especially as we ars proudly owned by the most beautiful and loving beagle in the world.It is a total contradiction to say that you are an animal lover to go to work every day to see sensitive loving animals confined to barron metal cages,and then to spend all your working day litterally poising them to death !!

    Andrea Jones

  5. Also they are not all captive breed monkeys many are captured from the wild and shipped thousands of miles to the uk.Heatrow airport has actualy had a brand new holding facility .pupose built to temporarily house these animals.Including beagles not just monkeys that are shipped in from America !!

    LIARS LIARS LIARS !!!
    Andrea jones

  6. because NO good never came from the suffering of others. ever. I want the world to stop being afraid and b proud of the beautiful web we are woven into. say YES to animal freedom, humans alike.

  7. We need to get this page up and running on facebook it is such a great platform for awareness, and there are so many more supporters we can reach!!

  8. Bravo à tous ceux et celles qui luttent contre l’espérimentation animale que ce soit en France ou partout dans le monde ! Il est prouvé qu’à l’heure actuelle les animaux comme les chiens et les singes ne sont pas nécessaire dans quelque recherche que ce soit !


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