Goldenthal has been performing toxicity testing on his beagles. Beagle dogs are the “species of choice” for these kinds of experiments as they are small, friendly, and co-operative. Typical experiments involve giving varying doses of a drug to twenty or thirty dogs, and observing the effects to see whether there is a build-up of toxic metabolites. Tests may be carried out for 4-6 weeks to investigate subacute toxicity, or up to two years to determine the chronic toxicity of the drug.
Researchers may administer the drugs intravenously, through an oral pill or solution, through inhalation, or by injections. The researcher then takes blood samples at regular intervals to investigate the effects of the drug. Animal experimenters often surgically implant catheters into the veins of the dog to make it easier to take samples. At the end of some experiments, the dogs are killed and dissected to determine the effect on their organs and tissues.
In one overseas experiment, beagle dogs were dosed with the drug avasimibe, causing vomiting, weight loss, salivation, and liver damage. Some dogs died of liver failure. In another experiment, the pesticide thiram was administered to 32 beagle dogs. Some of the dogs suffered severely, with nausea, vomiting, salivation, convulsions, liver failure, and kidney damage.